Search results for " Middle ear"

Expression of Matrix-Degrading Cysteine Proteinase Cathepsin K in Cholesteatoma

2001

Cholesteatoma is a nonneoplastic lesion of the middle ear space or mastoid that is histologically characterized by a progressive bone erosion of the ossicles and surrounding bone. Several matrix-degrading enzymes have been implicated as mediators of this bone erosion. Because the novel cysteine proteinase cathepsin K has been shown to play a central role in bone resorption, we examined the expression of this enzyme in tissue specimens of cholesteatoma. Tissue specimens of 9 patients with cholesteatoma were obtained during middle-ear surgery. Expression of cathepsin K mRNA was determined by RT-PCR using specific primers. Immunohistochemical analysis of cathepsin K protein expression in tissu…

The Role of Diffusion-Weighted Magnetic Resonance Imaging in Cholesteatoma Diagnosis and Follow-up: Study With the Diffusion PROPELLER Technique

2012

Abstract Introduction and objectives The diagnosis of cholesteatoma is based on clinical evaluation and computed tomography. New non-echo-planar diffusion-weighted magnetic resonance imaging (MRI) techniques, without intravenous contrast, are capable of differentiating cholesteatoma from inflammatory tissue, cholesterol granuloma and granulation tissues. The technique is very helpful in differential diagnosis of cholesteatoma, mainly after canal wall-up tympanoplasty surgery, to avoid routine second-look surgery in these patients. Congenital cholesteatoma and difficult cases can be detected and correctly diagnosed as well. The aim of this study was to evaluate sensitivity, specificity, posi…

Le fistole liquorali nella patologia otologica

2005

Cerebrospinal fluid fistulas in the otologic pathology show the presence of one or more anomalous touches between subaracnoids spaces and temporal bone. Cerebrospinal fluid fistulas are distinguished in congenital and acquired. The acquired fistulas are the most large group and they include post-traumatic fistulas, post-infective fistulas and/or post-inflammatory fistulas, iatrogenic fistulas, post-neoplastic fistulas and spontaneous fistulas. The congenital fistulas are more rare, they involve otic capsula and are, often, associated with malformations of inner ear. The critical analysis of our data leads, in our opinion, to some interesting diagnostic considerations. © Copyright 2005, CIC …

Cholesteatoma of the hypotympanum in a patient with Treacher Collins syndrome

2014

In the present article we report a cholesteatoma of the hypotympanum extending to the jugular foramen in a 16-year-old male with Treacher Collins syndrome. Preoperative imaging excluded jugular paraganglioma and set the diagnosis of cholesteatoma. We discuss the operative treatment via a large hypotympanotomy and creation of an open hypotympanic cavity. To the authors' knowledge this is the first description of hypotympanal cholesteatoma with such an extension, being treated through this approach.

Piezosurgery in the excision of middle ear tumors: effects on mineralized and non mineralized tissues

2007

BACKGROUND: Piezosurgery is a new instrument able to cut bone without necrosis and non-mineralized tissue damage. The aim of this study was to test the Piezosurgery as a new and alternative method for the excision of middle-ear tumors and to analyze its effects on soft tissues. MATERIAL/METHODS: The Piezosurgery device was used to excise eight glomus tympanicum tumors and two primary B-cell lymphomas of the middle ear. The piezoelectric device uses low-frequency ultrasonic waves (24.7-29.5 kHz); the applied power can be modulated between 2.8 and 16 W and is programmed in accordance to the density of the bone. The equipment consists of two hand-pieces, two inserts, and two peristaltic pumps.…

Cholesteatoma associated with Kabuki syndrome

2007

Kabuki syndrome (KS), also identified as Kabuki make-up syndrome or Niikawa-Kuroki syndrome, is a multiple malformation/mental retardation syndrome that was described initially in Japan but is now known to occur in many other ethnic groups. The syndrome is characterized by varying degrees of mental retardation, postnatal growth retardation, distinct facial characteristics resembling the Kabuki actor's make-up, cleft or high-arched palate, brachydactyly, scoliosis, and persistence of finger pads. There is no definitive laboratory diagnostic test for KS, thus diagnosis is based on phenotypic presentation and the exclusion of other known syndromes. Familial cases have been reported and autosom…

Otite media atelettasica, adesiva, timpanosclerotica: update medico e chirurgico

2011

Otitis media secretive is one of the most common ear diseases characterized by frequent sequelae and complications; in particular the authors describe middle ear atelectasis with pocket retraction of tympanic membrane, pocket retraction limited to pars tensa or to pars flaccida, adhesive otitis media, partial or total myringosclerosis and tympanosclerosis. For each disease the Authors comment the best surgical approaches to preserve and restore conductive hearing loss. As for middle ear atelectasis, adhesive otitis media, myringosclerosis and partial tympanosclerosis it was evidenced a significant hearing gain while in total tympanosclerosis there was an initial hearing improvement in a sho…

Current trends on subtotal petrosectomy with cochlear implantation in recalcitrant chronic middle ear disorders

2023

Objective. To establish the safety and effectiveness of subtotal petrosectomy with cochlear implantation in patients affected by chronic middle ear disorders to refractory to previous surgical treatments. Methods. A multicentre, retrospective study was conducted on patients affected by recalcitrant chronic middle ear disorders who underwent cochlear implantation in combi-nation with subtotal petrosectomy. Patients’ details were collected from databases of 11 Italian tertiary referral centres. Additionally, a review of the most updated literature was carried out. Results. 55 patients were included with a mean follow-up time of 44 months. Cholestea-toma was the most common middle ear recurren…

Customized approach for otogenic brain abscess: the neurosurgical prospective

2017

Surgical Management of Retraction Pockets: Does Mastoidectomy have a Role?

2021

Abstract Introduction Retraction pocket is a condition in which the eardrum lies deeper within the middle ear. Its management has no consensus in literature. Objective To assess the role of mastoidectomy in the management of retraction pockets added to a tympanoplasty. Methods Prospective study of patients with retraction pocket and referred to surgery. The patients were randomly assigned to two groups: one managed with tympanoplasty and mastoidectomy and the other group with tympanoplasty only. The minimum follow-up considered was 12 months. The outcomes were: integrity of eardrum, recurrence, and hearing status. Results This study included 43 patients. In 24 cases retraction occurred in t…